Pyrimidyl cyclopentanes as akt protein kinase inhibitors

Akt 단백질 키나제 억제제로서의 피리미딜 시클로펜탄


본 발명은 하기 화학식 I의 화합물, 및 그의 호변이성질체, 분리된 거울상이성질체, 부분입체이성질체, 용매화물, 대사물질, 염 및 제약상 허용되는 전구약물을 제공한다. 또한, 본 발명의 화합물을 AKT 단백질 키나제 억제제로서 사용하고 암과 같은 과다증식성 질환의 치료를 위해 사용하는 방법이 제공된다. <화학식 I>
The present invention provides compounds of Formula (I), including tautomers, resolved enantiomers, diastereomers, solvates, metabolites, salts and pharmaceutically acceptable prodrugs thereof. Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.




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